Department of Pathophysiology studied flushes the pathogenesis of the damage caused by the compounds of lead, chromium and vanadium on the body, and also examines the path correction and disorders as synthetic drugs (im-munomodulators and nanosorbent ) so and substances produced from domestic raw materials .

Topics Scientific Department of Research
1. “Molecular biological features of the course of aseptic inflammation associated
with ecological immunosuppression. “Scientificadviser: Balabekova M.K. 01.01.2015 – 30.12.2017
2. “Studies of the spectrum of metabolites of malignant and nodal neoplasms of
the thyroid gland in Kazakhstan.” Scientific adviser: Ablaev Zh.A. 01.01.2016 – 31.12.2016
3. “The role of CD4 + CD25 + Foxp3 + Tregs in the regulation of the inflammato-ry
process: metal – induced mechanisms of immunosuppression and the search for new methods of pathogenetic correction in experiment. ” Scientific advis-er: Balabekova M.K. 09/02/2019 – 09/30/2021.

Projects prepared and submitted for participation in the competition for grant financing of the Ministry of Education and Science of the Republic of Kazakhstan in co-authorship in 2017:
1. Analysis and validation of candidate genes – regulators of the inflammatory process and assessment of the effectiveness of their interaction with the original molecule of synthetic analogue of natural alkaloids under conditions of ecologically friendly immunosuppression. 2018.
2. Molecular – biological mechanisms of adaptation of the animal organism to the influence of external environmental factors.
3. New in the pathogenesis of disorders of tissue-specific genes and metabolic processes in animals caused by the combined effect of low doses of gamma ra-diation and heavy metal compounds.

Projects prepared and submitted for participation in the competition for intra-university grant funding:
1. Monitoring of the therapeutic efficacy of new drugs based on synthetic ana-logs of natural compounds (2018).
2. Study of post – translational modification of exosome proteins using a model of immobilization stress in rats of different age groups (2015).
3. Approbation of a new method for studying Treg expression activi-ty in splenocytes of mice with metal-induced immunodepression and search for new methods of correction (2017).